Publications & Posters

Publication

BET Inhibition Modifies Melanoma Infiltrating T Cells and Enhances Response to PD-L1 Blockade

https://doi.org/10.1016/j.jid.2018.12.024
Publication

ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition

  • AUTHORS Roberts, et al
  • Programs OPN-7486
https://doi.org/10.1182/blood-2018-05-849554
Publication

Blocking colony stimulating factor 1 receptor (CSF-1R) and tropomyosin receptor kinase A (TrkA) improves the antitumor efficacy of immune checkpoint blockade

  • AUTHORS Duffy, et al
  • Programs OPN-7486
https://www.jimmunol.org/content/200/1_Supplement/122.15/tab-article-info
Poster

Phase 1b/2a Study of PLX51107, a Small Molecule BET Inhibitor, in Subjects with Advanced Hematological Malignancies and Solid Tumors

  • AUTHORS Patnaik, et al
  • Programs OPN-2853
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Publication

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor

https://doi.org/10.1158/2159-8290.CD-17-0902
Publication

b2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

https://doi.org/10.1016/j.ccell.2017.11.007
Poster

Resistance to BET inhibitors involves the Wnt/β-catenin Pathway in Uveal Melanoma

  • AUTHORS Ambrosini, et al
  • Programs OPN-51107
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Publication

Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling

  • AUTHORS Hayakawa, et al
  • Programs OPN-7486
https://doi.org/10.1016/j.ccell.2016.11.005
Poster

Response and Resistance to Bromodomain Inhibition in Acute Myeloid Leukemia

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Poster

Broad Anti-Tumor Activity of a Novel BET Bromodomain Inhibitor

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